The HTC Fuze is based on the Microsoft Windows Mobile 6.1 Professional operating system. It integrates with Microsoft Outlook e-mail, contacts, calendar and to-do lists. Windows Mobile also lets users access and edit e-mail attachments using mobile versions of Microsoft Word, Excel, OneNote and PowerPoint. Additionally, the Fuze supports industry-specific applications and Microsoft System Center Mobile Device Manager, a mobile device management solution that also provides security, mobile VPN and software distribution for Windows Mobile devices.

The smart phone also works with Microsoft Direct Push e-mail and Xpress Mail, which lets users access work and personal e-mail accounts including not only Outlook, but Lotus Notes, Yahoo Mail, AOL, Windows Live and more.

And later this year the Fuze will also tie in Good Mobile Messaging and BlackBerry Connect compatibility.