No. 2: San Diego, Calif.
Between the University of California, San Diego and the UCSD Medical Center, San Diego leads the charge in health care and biotech development. As the second largest city in California, San Diego also plays home to a number of major telecom players like Qualcomm, which was founded and headquartered in San Diego, and wireless manufacturers Nokia and LG Electronics, to name a few. San Diego landed the No. 9 spot on Forbes' 2011 top tech city list, so it should come as no surprise that the average year-over-year salary growth saw a generous 13.4 percent increase, from $85,841 in 2011 to $97,328 in 2012, for a total increase of 34.9 percent between 2005 and 2012.