12. Cisco Systems
Fortune 500 Rank: No. 60
Revenue: $46.1 billion
Top Executive: CEO John Chambers
San Jose, Calif.-based Cisco, which raised its ranking this year from No. 64 in 2012, remains a leading vendor in networking technology and arguably one of the most important IT companies when it comes to the channel. With its Unified Computing System and participation in the VCE initiative with EMC and VMware, Cisco's influence is increasingly going beyond networking gear into other areas of computing.