3. Apple
Dec. 30, 2011: $405.00
Dec. 31, 2010: $322.56
Change: 25.6%
Apple suffered its greatest loss last year when co-founder and CEO Steve Jobs died of cancer. The company's stock lost almost $25 per share immediately and has yet to make it all back. Despite that setback, shares closed 2011 up more than 25 percent.
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